Human-Specific Hypomethylation of CENPJ, a Key Brain Size Regulator

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Human-specific hypomethylation of CENPJ, a key brain size regulator.

Both the enlarged brain and concurrent highly developed cognitive skills are often seen as distinctive characteristics that set humans apart from other primates. Despite this obvious differentiation, the genetic mechanisms that underlie such human-specific traits are not clearly understood. In particular, whether epigenetic regulations may play a key role in human brain evolution remain elusive...

متن کامل

Social life, evolution of intelligence, behaviour and human brain size

Social life is one of the most critical factors of the evolution of the behavior of non-human primates and humans. Several factors, such as an increase in brain size, adaptive modules, and grooming, are related to the complexities of social groups. Although some scientists have mentioned foraging as a rival hypothesis for the evolution of behavior, in this research, we tried to investigate the ...

متن کامل

A Life-size Human Brain

Each of the five senses activates a separate area of the cerebral cortex, the sheet of neurons that makes up the outer layer of the brain’s hemispheres. This brain, shown in actual size, is a computer reconstruction based on data from magnetic resonance imaging (MRI). Approximate locations of the primary sensory areas are shown in color. Most of the activity takes place within convolutions that...

متن کامل

Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome

Disruption of the centromere protein J gene, CENPJ (CPAP, MCPH6, SCKL4), which is a highly conserved and ubiquitiously expressed centrosomal protein, has been associated with primary microcephaly and the microcephalic primordial dwarfism disorder Seckel syndrome. The mechanism by which disruption of CENPJ causes the proportionate, primordial growth failure that is characteristic of Seckel syndr...

متن کامل

Fibroblast growth factor 1: a key regulator of human adipogenesis.

Obesity, with its related problems, is recognized as the fastest growing disease epidemic facing the world, yet we still have limited insight into the regulation of adipose tissue mass in humans. We have previously shown that adipose-derived microvascular endothelial cells (MVECs) secrete a factor(s) that increases proliferation of human preadipocytes. We now demonstrate that coculture of human...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Molecular Biology and Evolution

سال: 2013

ISSN: 1537-1719,0737-4038

DOI: 10.1093/molbev/mst231